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Natriuretic Peptide as predictor of cardiac risk

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Interesting development in the assessment of cardiac risk:


N-Terminal Pro-Brain Natriuretic Peptide, C-Reactive Protein, and Urinary Albumin Levels as Predictors of Mortality and Cardiovascular Events in Older Adults

Caroline Kistorp, MD; Ilan Raymond, MD, PhD; Frants Pedersen, MD; Finn Gustafsson, MD, PhD; Jens Faber, MD, DMSc; Per Hildebrandt, MD, DMSc

JAMA. 2005;293:1609-1616.

Context B-type natriuretic peptides have been shown to predict cardiovascular disease in apparently healthy individuals but their predictive ability for mortality and future cardiovascular events compared with C-reactive protein (CRP) and urinary albumin/creatinine ratio is unknown.

Objective To assess the prognostic value of the N-amino terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) vs CRP and urinary albumin/creatinine ratio in an older adult population.

Design, Setting, and Participants A population-based prospective study of 764 participants aged 50 to 89 years from a community in Copenhagen, Denmark, in which 658 participants provided blood and urinary samples and were examined between September 1, 1998, and January 24, 2000. Of these participants, 626 without heart or renal failure were enrolled. A subgroup of 537 had no history of cardiovascular disease at baseline. During 5 years of follow-up (to December 31, 2003), 94 participants died and 65 developed a first major cardiovascular event.

JAMA, April 2005

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Written by heartcurrents

March 2, 2010 at 6:59 am

Posted in heart conditions

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